Characterization of the mouse gene encoding the neuronal intermediate filament protein alpha-internexin
| Autor: | Chung-Liang Chien, R. K. H. Liem |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Untranslated region
Neurofilament Transcription Genetic Molecular Sequence Data Restriction Mapping Biology law.invention Exon Mice Intermediate Filament Proteins law Genetics Coding region Animals Amino Acid Sequence RNA Messenger Cloning Molecular Intermediate filament Gene Conserved Sequence Neurons Base Sequence Sequence Homology Amino Acid Intron General Medicine Exons Blotting Northern Molecular biology Introns Rats Multigene Family Recombinant DNA Carrier Proteins |
| Zdroj: | Gene. 149(2) |
| ISSN: | 0378-1119 |
| Popis: | We have determined the complete nucleotide (nt) sequence of the coding region of the mouse gene encoding the neuronal intermediate filament protein, alpha-internexin (alpha INX). The mouse alpha INX gene (m alpha INX) contains three exons and two introns, and may be classified as a member of the type-IV intermediate filament multigene family. The nt sequence of the transcribed region of m alpha INX shows high homology to that of the rat gene. Comparison of the deduced amino-acid sequences between the mouse and rat gene products reveals that the head and rod domains are highly conserved. However, the tail domains show significant differences which may make it possible to raise specific antibodies that can distinguish the alpha INX of mouse from that of rat. |
| Databáze: | OpenAIRE |
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