Emotional and Behavioral Outcomes in Childhood for Survivors of Invasive Group B Streptococcus Disease in Infancy: Findings From 5 Low- and Middle-Income Countries
| Autor: | Santhanam Sridhar, Hima B John, Ziyaad Dangor, Jaya Chandna, Amina Abubakar, Shannon Leahy, Proma Paul, Romina Libster, Kate Milner, Humberto Mucasse, Azucena Bardají, Wan-Hsin Liu, Charles R. Newton, Carophine Nasambu, Joy E Lawn, Quique Bassat, Clara Sánchez Yanotti |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty neonatal sepsis Supplement Articles CBCL Disease Group B Strep Group B Streptococcus agalactiae Cohort Studies emotional behavior medicine Humans Survivors Child Developing Countries neurodevelopment Neonatal sepsis business.industry Infant Newborn Infant medicine.disease Checklist AcademicSubjects/MED00290 Infectious Diseases Low and middle income countries Income Anxiety medicine.symptom business Meningitis |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Survivors of invasive group B Streptococcus (iGBS) disease, notably meningitis, are at increased risk of neurodevelopmental impairment. However, the limited studies to date have a median follow-up to 18 months and have mainly focused on moderate or severe neurodevelopmental impairment, with no previous studies on emotional-behavioral problems among iGBS survivors. Methods In this multicountry, matched cohort study, we included children aged 18 months to 17 years with infant iGBS sepsis and meningitis from health demographic surveillance systems, or hospital records in Argentina, India, Kenya, Mozambique, and South Africa. Children without an iGBS history were matched to iGBS survivors for sex and age. Our primary outcomes were emotional-behavioral problems and psychopathological conditions as measured with the Child Behavior Checklist (CBCL). The CBCL was completed by the child’s primary caregiver. Results Between October 2019 and April 2021, 573 children (mean age, 7.18 years) were assessed, including 156 iGBS survivors and 417 non-iGBS comparison children. On average, we observed more total problems and more anxiety, attention, and conduct problems for school-aged iGBS survivors compared with the non-iGBS group. No differences were found in the proportion of clinically significant psychopathological conditions defined by the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). Conclusions Our findings suggested that school-aged iGBS survivors experienced increased mild emotional behavioral problems that may affect children and families. At-risk neonates including iGBS survivors need long-term follow-up with integrated emotional-behavioral assessments and appropriate care. Scale-up will require simplified assessments that are free and culturally adapted. |
| Databáze: | OpenAIRE |
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