The Effect of Methylphenidate on Reed Scaling in Benzodiazepine Poisoning: A Prospective Trial
| Autor: | Mitra Rahimi, Helya Sadat Mortazavi, Masoud Latifi-Pour, Nasim Zamani, Hossein Hassanian-Moghaddam, Shahin Shadnia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Consciousness Referral medicine.drug_class medicine.medical_treatment methylphenidate Unconsciousness Iran Placebo Article central nervous system stimulants Benzodiazepines Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method 030225 pediatrics Internal medicine medicine Humans Intubation Pharmacology (medical) Prospective Studies 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Benzodiazepine Methylphenidate business.industry clinical trial General Medicine Middle Aged medicine.disease Acute toxicity poisoning Clinical trial Substance abuse Bicarbonates Treatment Outcome placebo effect Female business medicine.drug |
| Zdroj: | Current Clinical Pharmacology |
| ISSN: | 1574-8847 |
| DOI: | 10.2174/1574884714666190112153157 |
| Popis: | Background: Benzodiazepine is one of the most important causes of substance abuse and intoxication throughout the world and Iran. Objective: The aim of our study is to determine the role of stimulants in reversing CNS level in acute Benzodiazepine poisoning patients who were hospitalized at referral poison center. Methods: This was a randomized double-blind placebo-controlled trial study on 32 cases with pure acute Benzodiazepine poisoning from March 2016 to February 2017. Diagnosis of pure acute poisoning was based on history, and laboratory confirmation. We gathered the demographics, clinical data, laboratory data, hospitalization and outcome. Participants were randomized into two groups: Methylphenidate Group (MPH) and Placebo Group (PBO). Results: The randomized sample consisted of 32 participants who were predominately female (83%). The majority of the PBO group and the MPH group reported improvement in their consciousness with a significant difference between the two groups (p = .005). Paired sample t-test analyses on Reed Scale data revealed an increase in the probability of improvement during the trial for the MPH group compared to the PBO group. Furthermore, the HCo3 (bicarbonate) level has a significant p-value with respect to age groups (p = .02). None of our cases required either the ICU facility or intubation. Conclusion: Our study provided the MPH superiority over PBO in reversing CNS symptoms in loss of consciousness in acute BZD poisoned patients. Thus, this trial provides concrete evidence that improvement in consciousness levels (Reed Scale rated) among those patients receiving MPH was associated with a methylphenidate use. |
| Databáze: | OpenAIRE |
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