Novel Biomarkers in Heart Failure: New Insight in Pathophysiology and Clinical Perspective
| Autor: | Luigi M. Biasucci, Alessandro Maino, Luigi Cappannoli, Maria Chiara Grimaldi, Nadia Aspromonte |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Complex disease heart failure Review 030204 cardiovascular system & hematology noncoding RNA 03 medical and health sciences 0302 clinical medicine medicine Intensive care medicine Clinical syndrome 030304 developmental biology 0303 health sciences business.industry fibrosis General Medicine Precision medicine medicine.disease Brain natriuretic peptide Omics inflammation Heart failure Medicine Biomarker (medicine) biomarker Personalized medicine business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2771, p 2771 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Heart failure (HF) is a complex clinical syndrome with a huge social burden in terms of cost, morbidity, and mortality. Brain natriuretic peptide (BNP) appears to be the gold standard in supporting the daily clinical management of patients with HF. Novel biomarkers may supplement BNP to improve the understanding of this complex disease process and, possibly, to personalize care for the different phenotypes, in order to ameliorate prognosis. In this review, we will examine some of the most promising novel biomarkers in HF. Inflammation plays a pivotal role in the genesis and progression of HF and, therefore, several candidate molecules have been investigated in recent years for diagnosis, prognosis, and therapy monitoring. Noncoding RNAs are attractive as biomarkers and their potential clinical applications may be feasible in the era of personalized medicine. Given the complex pathophysiology of HF, it is reasonable to expect that the future of biomarkers lies in the application of precision medicine, through wider testing panels and “omics” technologies, to further improve HF care delivery. |
| Databáze: | OpenAIRE |
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