Polycythemia vera and myelofibrosis: correlation of MR imaging, clinical, and laboratory findings
| Autor: | D L Burk, Matthew D. Rifkin, S. Murphy, Robert M. Steiner, Simon Vinitski, Vijay M. Rao, Donald G. Mitchell, K. R. Kaplan |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Greater trochanter medicine.medical_specialty Pathology Spleen Gastroenterology chemistry.chemical_compound Polycythemia vera Bone Marrow Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Femur Myelofibrosis Polycythemia Vera Aged Retrospective Studies Aged 80 and over Lumbar Vertebrae L-Lactate Dehydrogenase medicine.diagnostic_test business.industry Cholesterol Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Mr imaging medicine.anatomical_structure chemistry Primary Myelofibrosis Epiphysis Splenomegaly Female business |
| Zdroj: | Radiology. 183:329-334 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | Magnetic resonance (MR) imaging was performed in 14 patients with biopsy-proved polycythemia vera (n = 4) or myelofibrosis (n = 10) to determine whether MR imaging findings can be correlated with the clinicopathologic diagnosis and established clinical parameters of severity (serum lactate dehydrogenase [LDH] and cholesterol levels) and chronicity (spleen size). Evaluation of marrow in the proximal femurs showed that patients could be categorized into three distinct groups based on anatomic patterns of normal fatty and abnormal low-signal-intensity (non-fatty) marrow in the femoral capital epiphysis (FCE) and greater trochanter (GT). Patients with nonfatty marrow in both the FCE and GT (n = 8) had significantly higher serum LDH (P less than .02) and lower serum cholesterol (P less than .02) levels than patients with fatty marrow in at least the GT (n = 6). Splenic volume, as measured from MR images, was significantly greater in the myelofibrosis group than in the polycythemia vera group (P less than .001). MR imaging provided a better understanding of these hematologic disorders and novel parameters for classification that are different from conventional histologic and laboratory data. |
| Databáze: | OpenAIRE |
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