Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study
| Autor: | Philip L. Molyneaux, Maria Molina-Molina, Felix Chua, Siva Mahendran, R K Coker, Pilar Rivera-Ortega, Maria Kokosi, George Margaritopoulos, Alice Packham, Alex West, Suresh Babu, Joanna C. Porter, Nazia Chaudhuri, Elisabeth Bendstrup, Michael Henry, Sharon Sturney, Ewen M Harrison, Tim Wallis, Athol U. Wells, Peter J. M. Openshaw, Louise E. Crowley, Laura Mackay, Elisabetta A. Renzoni, Glenn Hearson, Lisa G. Spencer, Iain A. Stewart, Killian Hurley, Ian Forrest, Diego Castillo Villegas, Sarah Agnew, Thomas M Drake, Simon P. Hart, Gauri Saini, Katherine M.A. O'Reilly, Huzaifa Adamali, Annemarie B Docherty, Jennifer K Quint, J Kenneth Baillie, Muhunthan Thillai, Rachel K. Hoyles, Katie Ward, Melissa Wickremasinghe, Michael A Gibbons, Malcolm G Semple, Davinder Dosanjh, Venerino Poletti, John M. Hutchinson, Helen Parfrey, R. Gisli Jenkins, David R Thickett, Aiden O’Brien, Lucy Howard, Emily Heiden, Michael Kreuter, Shaney L Barratt, Isaric C Investigators, Chris Barber, Anne-Marie Russell, Katherine Groom, S Jones, Stephen Bianchi, Christine A Fiddler, Giulia M. Stella, Anjali Crawshaw, Sarah Haney, Ling-Pei Ho, Helen Stone, William Chang, Peter M. George, Mark Jones, Felix Woodhead |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
Vital capacity medicine.medical_specialty business.industry Population Interstitial lung disease respiratory system medicine.disease Comorbidity behavioral disciplines and activities Confidence interval respiratory tract diseases body regions FEV1/FVC ratio Internal medicine Cohort Medicine In patient education business |
| DOI: | 10.1101/2020.07.15.20152967 |
| Popis: | RationaleThe impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established.ObjectivesTo assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population.MethodsAn international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death.Measurements and Main ResultsData from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and comorbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of ConclusionsPatients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD. |
| Databáze: | OpenAIRE |
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