Glomerular lesion and increased cytokine gene expression in renal tissue in patients with decompensated nephrotic syndrome due to chronic GvHD
| Autor: | A Lange, Marian Klinger, B Tyran, K Suchnicki, Dorota Kamińska, O Vakulenko, Agnieszka Hałoń, Oktawia Mazanowska, J Kuzniar, B Bernat |
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| Rok vydání: | 2010 |
| Předmět: |
Interleukin 2
Adult Male Pathology medicine.medical_specialty Nephrotic Syndrome Nephrosis Gene Expression Graft vs Host Disease Critical Care and Intensive Care Medicine Diagnosis Differential medicine Humans Interferon gamma Minimal change disease biology medicine.diagnostic_test business.industry Reverse Transcriptase Polymerase Chain Reaction Nephrosis Lipoid General Medicine Transforming growth factor beta medicine.disease Transplantation Nephrology biology.protein Cytokines Renal biopsy business Nephrotic syndrome medicine.drug |
| Zdroj: | Renal failure. 32(4) |
| ISSN: | 1525-6049 |
| Popis: | The nephrotic syndrome is a rare complication of allogeneic stem cell transplantation (alloHSCT). We present two cases of nephrotic syndrome during chronic graft-versus-host disease (GvHD) involving altered cytokine gene expression in renal tissue. A patient with acute lymphatic leukemia demonstrated nephrotic syndrome due to minimal change disease as a marker of chronic GvHD. A patient with acute lymphoblastic leukemia suffered from severe nephrotic syndrome due to membranous glomerulopathy. In the two presented cases of GvHD-linked nephrotic syndrome, increased cytokine gene expression [tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma), interleukin 2 (IL-2), IL-6, and IL-10] assessed using semiquantitative evaluation with reverse transcriptase polymerase chain reaction (RT-PCR) in situ on renal biopsy was observed. |
| Databáze: | OpenAIRE |
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