Evaluation of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer Using Ultrasound Elastography
| Autor: | Martin J. Yaffe, Ervis Sofroni, Ali Sadeghi-Naini, Gregory J. Czarnota, Jean Francois Boileau, Sameera Prematilake, Eileen Rakovitch, Judit Zubovits, Jean-Philippe Pignol, Sara Iradji, Omar Falou, Maureen E. Trudeau, Rebecca Dent, Zahra Jahedmotlagh, Jacqueline Spayne, Sharon Lemon-Wong, Frances C. Wright, Naum Papanicolau |
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| Jazyk: | angličtina |
| Předmět: |
Cancer Research
medicine.medical_specialty Treatment response medicine.medical_treatment Locally advanced lcsh:RC254-282 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Ultrasound elastography Neoadjuvant therapy Chemotherapy business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 3. Good health Surgery Oncology 030220 oncology & carcinogenesis Radiology business Chemotherapy response Mastectomy Research Article |
| Zdroj: | Translational Oncology, Vol 6, Iss 1, Pp 17-24 (2013) |
| ISSN: | 1936-5233 |
| DOI: | 10.1593/tlo.12412 |
| Popis: | PURPOSE: Ultrasound elastography is a new imaging technique that can be used to assess tissue stiffness. The aim of this study was to investigate the potential of ultrasound elastography for monitoring treatment response of locally advanced breast cancer patients undergoing neoadjuvant therapy. METHODS: Fifteen women receiving neoadjuvant chemotherapy had the affected breast scanned before, 1, 4, and 8 weeks following therapy initiation, and then before surgery. Changes in elastographic parameters related to tissue biomechanical properties were then determined and compared to clinical and pathologic tumor response after mastectomy. RESULTS: Patients who responded to therapy demonstrated a significant decrease (P < .05) in strain ratios and strain differences 4 weeks after treatment initiation compared to non-responding patients. Mean strain ratio and mean strain difference for responders was 81 ± 3% and 1 ± 17% for static regions of interest (ROIs) and 81 ± 3% and 6 ± 18% for dynamic ROIs, respectively. In contrast, these parameters were 102±2%, 110±17%, 101±4%, and 109±30% for non-responding patients, respectively. Strain ratio using static ROIs was found to be the best predictor of treatment response, with 100% sensitivity and 100% specificity obtained 4 weeks after starting treatment. CONCLUSIONS: These results suggest that ultrasound elastography can be potentially used as an early predictor of tumor therapy response in breast cancer patients. |
| Databáze: | OpenAIRE |
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