Endoplasmic Reticulum Protein Quality Control in β cells
| Autor: | Ling Qi, Rachel B. Reinert, Neha Shrestha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
β cell function Endoplasmic reticulum Autophagy Membrane Proteins Cell Biology Biology Disease pathogenesis Endoplasmic-reticulum-associated protein degradation Endoplasmic Reticulum Article Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Insulin-Secreting Cells Unfolded protein response Diabetes Mellitus Humans Protein quality 030217 neurology & neurosurgery Function (biology) Developmental Biology |
| Zdroj: | Semin Cell Dev Biol |
| Popis: | Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded protein response (UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β cells. We propose that different quality control mechanisms may control different aspects of β cell biology (i.e. function, survival, and identity), thereby contributing to disease pathogenesis. |
| Databáze: | OpenAIRE |
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