Polygenic control of autoimmune diabetes in nonobese diabetic mice
| Autor: | S. Ghosh, S.M. Palmer, N.R. Rodrigues, H.J. Cordell, C.M. Hearne, R.J. Cornall, J.-B. Prins, P. McShane, G.M. Lathrop, L.B. Peterson, L.S. Wicker, J.A. Todd |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Genetic Markers
Male DNA Complementary Genetic Linkage Molecular Sequence Data Nod Biology ENCODE Genome Autoimmune Diseases Lesion Mice Mice Inbred NOD Diabetes mellitus Genetics medicine Animals Amino Acid Sequence Crosses Genetic chemistry.chemical_classification Base Sequence Chromosome Mapping Pancreatic Diseases medicine.disease Amino acid Mice Inbred C57BL Diabetes Mellitus Type 1 chemistry Oligodeoxyribonucleotides Interleukin-2 Regression Analysis Female medicine.symptom Candidate Disease Gene Insulitis |
| Popis: | Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the pre–diabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using a new application of multiple polychotomous regression methods. A candidate disease gene, interleukin–2 (Il–2), which is closely linked to insulitis and diabetes, is shown to have a different sequence in NOD, including an insertion and a deletion of tandem repeat sequences which encode amino acid repeats in the mature protein. |
| Databáze: | OpenAIRE |
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