Ocular penetration of oral doxycycline in the horse
| Autor: | Jacqueline M. Dedeo, Martin Pugh, Margi A. Gilmour, David L. Caudell, Charles G. MacAllister, Rebecca J. Morton, Cyril R. Clarke |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
genetic structures Administration Oral Biological Availability Ocular penetration Pharmacology Aqueous Humor Uveitis Oral administration Animals Medicine Horses Doxycycline General Veterinary business.industry Drug administration Horse Equine recurrent uveitis Serum concentration eye diseases Anti-Bacterial Agents Surgery Vitreous Body Area Under Curve Female Horse Diseases sense organs business Intraocular penetration medicine.drug |
| Zdroj: | Veterinary Ophthalmology. 8:331-335 |
| ISSN: | 1463-5224 1463-5216 |
| Popis: | Objective To investigate intraocular penetration of orally administered doxycycline in the normal equine eye and to compare intraocular and serum doxycycline concentrations. Procedures Six mares were administered doxycycline at 10 mg/kg every 12 h by nasogastric tube for 5 days. Blood, aqueous, and vitreous samples were collected on days 1 and 5. All samples were assayed for doxycycline concentrations. Aqueous and vitreous samples were also assayed for protein quantitation. Results Doxycycline was rapidly absorbed after the first dose (Tmax value of 1.42 ± 1.28 h); and elimination of doxycycline occurred slowly (median t1/2 = 10.88 h). Doxycycline could not be detected in the aqueous on days 1 and 5, nor could it be detected in the vitreous on day 1. On day 5, the mean vitreous doxycycline concentration was 0.17 ± 0.04 µg/mL at 2 h after drug administration. Conclusions Repeated oral administration of doxycycline in the horse resulted in steady state serum concentrations of |
| Databáze: | OpenAIRE |
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