Utility of Measurement of Interleukin-1ß and Interleukin-8 in the Diagnosis of Complicated Parapneumonic Pleural Effusions
| Autor: | Francisco J. González-Barcala, M. Esther Soneira, Antonio Golpe, M. Esther San José, Luis Valdés, M. Carmen Vázquez, Lucía Ferreiro |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Pleural effusion medicine.medical_treatment Interleukin-1beta Sensitivity and Specificity Gastroenterology Parapneumonic effusion Young Adult Internal medicine medicine Humans Pleurisy Empyema Pleural Aged Aged 80 and over L-Lactate Dehydrogenase business.industry Interleukin-8 Area under the curve Interleukin Pneumonia General Medicine Hydrogen-Ion Concentration Middle Aged medicine.disease Empyema Surgery Pleural Effusion Chest tube Early Diagnosis Glucose ROC Curve Effusion business Biomarkers |
| Zdroj: | American Journal of Clinical Pathology. 142:467-473 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Thirty percent of patients with pneumonia develop pleural effusion, and of these, 20% have complicated effusion (CPPE), which may require a chest tube or surgery for resolution. The objective of the study is to compare the diagnostic yield of determining interleukin-1β and interleukin-8 in pleural fluid (PF) (PFIL-1β and PFIL-8) with respect to classic criteria (pH7.2, lactate dehydrogenase [LD]1,000 IU/mL, and/or glucose60 mg/dL) in the early diagnosis of CPPE.Of the 559 patients studied, 40 had CPPE. All underwent PF analysis: pH, glucose (PFGLUC), LD (PFLD), PFIL-1β and PFIL-8, and PF/serum ratios (PF/SIL-1β and PF/SIL-8).The diagnostic criterion that showed the best area under the curve was the combination of PF/SIL-8 and PFIL-1β (0.906), with a statistically significant difference (P.05) compared with the classic criterion of pH and PFGLUC or PFLD (0.826). The combination of PF/SIL-8 and PFIL-1β (cutoffs5.73 and9.14 pg/mL, respectively) was significantly more sensitive (72.7%) and more specific (97.9%) (P.05) than the rest of the parameters used.Measurement of IL-1β and IL-8 in pleural fluid may be useful in the early diagnosis of CPPE, although individually, it may not improve the results obtained with the PFLD. Further studies are needed to more firmly establish what role these new parameters can play in the diagnosis of CPPE. |
| Databáze: | OpenAIRE |
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