Au Nanocage-Strengthened Dissolving Microneedles for Chemo-Photothermal Combined Therapy of Superficial Skin Tumors
| Autor: | Yajie Zhou, Liu Pei, Liyun Dong, Ke Wang, Jun Xie, Jintao Zhu, Zhao Li, Zhu Jinjin, Nan Xu, Yuce Li, Huang Yuqiong, Yamin Zhang, Chen Shen, Juan Tao, Du Hongyao, Guichao Ren |
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| Rok vydání: | 2018 |
| Předmět: |
Skin Neoplasms
Materials science Side effect medicine.medical_treatment 02 engineering and technology Administration Cutaneous 010402 general chemistry 01 natural sciences Mice chemistry.chemical_compound Hyaluronic acid medicine Stratum corneum Animals General Materials Science Doxorubicin Transdermal Chemotherapy integumentary system Photothermal effect Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology Nanostructures 0104 chemical sciences medicine.anatomical_structure chemistry Needles Gold 0210 nano-technology medicine.drug Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 10:9247-9256 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | For superficial skin tumors (SST) with high incidence, surgery and systemic therapy are relatively invasive and possible to cause severe side effect, respectively. Yet, topical therapy is confronted with the limited transdermal capacity because of the stratum corneum barrier layer of skin. Therefore, it is crucial to develop a highly effective and minimally invasive alternative transdermal approach for treating SST. Here, we developed gold nanocage (AuNC)- and chemotherapeutic drug doxorubicin (DOX)-loaded hyaluronic acid dissolving microneedle (MN) arrays. The loaded AuNCs are not only reinforcers to enhance the mechanical strength of the MNs, but also effective agents for photothermal therapy to obtain effective transdermal therapy for SST. The resultant MNs can effectively penetrate the skin, dissolve in the skin and release cargoes within the tumor site. Photothermal effect of AuNCs initiated by near-infrared laser irradiation combined with the chemotherapy effect of DOX destroyed tumors synergistically. Moreover, we verified the potent antitumor effects of the DOX/AuNC-loaded MNs after four administrations to SST-bearing mice without obvious side effects. Therefore, the drug/AuNC-loaded dissolving MN system provides a promising platform for effective, safe, minimally invasive combined treatment of SST. |
| Databáze: | OpenAIRE |
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