Cellular density of low-grade transition zone prostate cancer: A limiting factor to correlate restricted diffusion with tumor aggressiveness
| Autor: | Matthias Barral, François Cornud, Philippe Camparo, Philippe Soyer, Aida Jemal-Turki, Frédéric Beuvon |
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| Přispěvatelé: | Centre de pathologie |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty [SDV]Life Sciences [q-bio] Urology Cell Count 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Humans Medicine Effective diffusion coefficient Radiology Nuclear Medicine and imaging Multiparametric Magnetic Resonance Imaging Aged Retrospective Studies Aged 80 and over Prostatectomy Cellular density business.industry Prostatic Neoplasms Mean age General Medicine Middle Aged Glandular Cell medicine.disease Peripheral zone medicine.anatomical_structure 030220 oncology & carcinogenesis Prostate neoplasm Neoplasm Grading business |
| Zdroj: | European Journal of Radiology European Journal of Radiology, Elsevier, 2020, 131, pp.109230-. ⟨10.1016/j.ejrad.2020.109230⟩ |
| ISSN: | 0720-048X |
| Popis: | Objective To compare the mean apparent diffusion coefficient (ADCmean) and glandular density of Gleason score (GS) 3 + 3 transition zone prostate cancers (TZ-PCa) with those of the peripheral zone (PZ-PCa). Material & methods Seventy-nine men (mean age: 65 ± 6 [SD] years; range: 52–81 years) with 37 TZ-PCa (37/79; 53 %) and 42 PZ-PCa (42/79; 47 %) had prostate MRI before radical prostatectomy. Glandular cell density was semi-quantitatively evaluated in all tumors. ADCmean and glandular cell density of GS3 + 3 TZ-PCa were compared to those of PZ-PCa. ADCmean was correlated to GS in each zone. Results ADCmean of GS 3 + 3 tumors was significantly lower in the TZ (728 × 10−6±52 [SD] mm²/s; range: 670−1060mm²/s) than in the PZ (865 × 10−6 ±121 [SD] mm²/s; range: 670−1120mm²/s) (p = 0.0007), related to a significantly higher glandular density involving more than 50 % of the tumor in 58 % (7/12) of patients in GS3 + 3 TZ-PCa versus 7.6 % (1/13) in PZ-PCa (p = 0.03). ADCmean of GS3 + 3 TZ-PCa was not significantly different from that of GS 3 + 4 (p = 0.14) or GS>3 + 4 Ca (p = 0.9), whatever the zone of origin. In the PZ, ADCmean of GS 3 + 3-PCa was higher than that of Gleason>3 + 4 PZ-PCa (p = 0.02) and similar to that of GS 3 + 4 PZ-PCa (p = 0.24). Correlation between ADCmean and GS was weak for TZ-PCa (ρ = 0.32; p = 0.04) and moderate for PZ-PCa (ρ = 0.45; p = 0.003). Conclusion ADCmean of GS 3 + 3 TZ-PCa is significantly lower than that of GS 3 + 3 PZ-PCa, related to a unique dense histological pattern and reaches that of higher-grade PCa, whatever the zone of origin. |
| Databáze: | OpenAIRE |
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