Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus
| Autor: | Ben A. M. van der Zeijst, Thijs Kuiken, Hubert G. M. Niesters, Geert van Amerongen, Albert D. M. E. Osterhaus, Luis Mateo, Koert J. Stittelaar, Paul Chaplin, Frank H. M. Pistoor, Ivanela Kondova, Gerard J. J. van Doornum, Rob van Lavieren |
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| Přispěvatelé: | Virology |
| Rok vydání: | 2005 |
| Předmět: |
T-Lymphocytes
viruses Immunology Vaccinia virus Antibodies Viral complex mixtures Microbiology Dryvax Monkeypox chemistry.chemical_compound SDG 3 - Good Health and Well-being Virology Vaccines and Antiviral Agents medicine Animals Humans Poxviridae Orthopoxvirus Monkeypox virus Smallpox vaccine Lung Respiratory Tract Infections Skin biology virus diseases ACAM2000 biology.organism_classification medicine.disease Disease Models Animal Macaca fascicularis chemistry Insect Science Immunization Vaccinia Smallpox Vaccine |
| Zdroj: | Journal of Virology, 79(12), 7845-7851. American Society for Microbiology |
| ISSN: | 0022-538X |
| Popis: | The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naïve and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical VV-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox. |
| Databáze: | OpenAIRE |
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