Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats
| Autor: | N. Castanon, Pierre Mormède, Xinmin Fan, E. D. Hendley |
|---|---|
| Přispěvatelé: | Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Université de Bordeaux Ségalen [Bordeaux 2] |
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Physiology Corticotropin-Releasing Hormone [SDV]Life Sciences [q-bio] Blood Pressure Adrenocorticotropic hormone Hyperkinesis Motor Activity Plasma renin activity Rats Inbred WKY Open field 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Inbred strain Adrenocorticotropic Hormone Acth response Corticosterone Physiology (medical) Internal medicine Rats Inbred SHR Renin medicine Animals 030304 developmental biology 0303 health sciences Aldosterone Behavior Animal Rats Inbred Strains Neurosecretory Systems Prolactin Rats Endocrinology chemistry CRH Hypertension RAT Psychology 030217 neurology & neurosurgery |
| Zdroj: | AJP-Regulatory, Integrative and Comparative Physiology AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 1993, 265 (6), pp.R1304-R1310. ⟨10.1152/ajpregu.1993.265.6.R1304⟩ |
| ISSN: | 0002-9513 0363-6119 1522-1490 |
| Popis: | The behavioral and neuroendocrine reactivity to a novel environment (open field) and the adrenocorticotropic hormone (ACTH)/corticosterone response to a corticotropin-releasing factor (CRF) challenge were measured in 2-mo-old rats from four inbred strains derived from the Wistar-Kyoto rat: spontaneously hypertensive rats (SHRs), hypertensive and behaviorally hyperactive to novelty; WKY, neither hypertensive nor hyperactive; WKHA, hyperactive but normotensive; and WKHT, only hypertensive. The ACTH response to CRF was much lower in SHRs than WKYs, this reduced reactivity being clearly associated with the hyperactivity trait, since it was present in the WKHA and absent in the WKHT strain. On the other hand, the ACTH/corticosterone response to a psychological stimulus (open field) could not clearly discriminate the four strains. The largest difference was found in the prolactin response. Post-open-field levels were much lower in the WKHA (27.11 +/- 4.69 ng/ml) than in the parent WKY strain (83.65 +/- 6.84 ng/ml), the hypertensive strains having intermediate levels (WKHT: 58.05 +/- 7.65 ng/ml; SHR: 64.13 +/- 7.19 ng/ml). Other differences were also found in the levels of aldosterone and renin activity. These results indicate that these strains are an excellent model to study neuroendocrine correlates of hypertension and hyperactivity, which are associated in the SHR strain and may be of interest for the study of the association between neuroendocrine and behavioral characteristics. |
| Databáze: | OpenAIRE |
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