MR1 encompasses at least six allele groups with coding region alterations

Autor: Sidonia B G Eckle, Erik H. Rozemuller, Ian J. McLaughlin, Wietse Mulder, Maarten T. Penning, Sake van Wageningen, Helma de Bruin
Rok vydání: 2021
Předmět:
Zdroj: HLAREFERENCES. 98(6)
ISSN: 2059-2310
Popis: Unlike classical HLA class I genes, MR1 is assumed to have limited polymorphic positions. We developed a MR1 specific PCR assay and sequenced 56 DNA samples from cells with a diverse set of HLA genotypes. In this relatively small panel we found six allele groups encoding for different MR1 proteins. The two most frequent allele groups found in this panel had a frequency of 71% (MR1*01) and 25% (MR1*02), respectively. Moreover, the panel contained many intronic SNPs and silent variants, with individual samples containing up to 15 heterozygous positions. The data presented here is consistent with marked variation in MR1.
Databáze: OpenAIRE
Nepřihlášeným uživatelům se plný text nezobrazuje