Potential roles of mediator Complex Subunit 13 in Cardiac Diseases
| Autor: | Lu Cai, Yang Zheng, Jia Li, Hongbo Men, He Xu, Xiang Wang, Wenqian Zhou, He Cai |
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| Rok vydání: | 2021 |
| Předmět: |
Heart Diseases
Protein subunit Review Biology Applied Microbiology and Biotechnology Energy homeostasis 03 medical and health sciences Mediator energy metabolism medicine Animals Humans Molecular Biology Gene Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Mediator Complex Kinase Receptor Cross-Talk Cell Biology medicine.disease MED13 cardiovascular diseases Cell biology Oxidative Stress Nuclear receptor Heart failure Cyclin-dependent kinase 8 Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| DOI: | 10.7150/ijbs.52290 |
| Popis: | Mediator complex subunit 13 (MED13, previously known as THRAP1 and TRAP240) is a subunit of the cyclin-dependent kinase 8 (CDK8) kinase module in the eukaryotic mediator complex. MED13 has been known to play critical roles in cell cycle, development, and growth. The purpose of this review is to comprehensively discuss its newly identified potential roles in myocardial energy metabolism and non-metabolic cardiovascular diseases. Evidence indicates that cardiac MED13 mainly participates in the regulation of nuclear receptor signaling, which drives the transcription of genes involved in modulating cardiac and systemic energy homeostasis. MED13 is also associated with several pathological conditions, such as metabolic syndrome and thyroid disease-associated heart failure. Therefore, MED13 constitutes a potential therapeutic target for the regulation of metabolic disorders and other cardiovascular diseases. |
| Databáze: | OpenAIRE |
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