Elevated level of lecithin:cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden

Autor: Marie-Claude Guertin, Catherine Gebhard, Josep Rodés-Cabau, Jean-Claude Tardif, Reda Ibrahim, Rob S. Beanlands, Eric Rhéaume, Simon Kouz, Shahar Lavi, Gang He, Mariève Cossette, Lawrence M. Title, Jean Grégoire, Philippe L. L’Allier, David Rhainds, J. David Spence
Přispěvatelé: University of Zurich, Tardif, Jean-Claude
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Canada
medicine.medical_specialty
Sterol O-acyltransferase
610 Medicine & health
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Severity of Illness Index
2705 Cardiology and Cardiovascular Medicine
Phosphatidylcholine-Sterol O-Acyltransferase
11459 Center for Molecular Cardiology
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Humans
Medicine
Ultrasonography
Interventional
Aged
business.industry
Cholesterol
Reverse cholesterol transport
10181 Clinic for Nuclear Medicine
Middle Aged
Protective Factors
Stepwise regression
medicine.disease
Coronary Vessels
Lipids
Plaque
Atherosclerotic
Up-Regulation
3. Good health
030104 developmental biology
Atheroma
chemistry
Quartile
Case-Control Studies
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Lipoprotein
Zdroj: Atherosclerosis. 276:131-139
ISSN: 0021-9150
Popis: BACKGROUND AND AIMS Lecithin:cholesterol acyltransferase (LCAT), a key enzyme in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT), has been associated with atheroprotection. However, its relation to plaque characteristics has not been confirmed to date. We aimed to determine the relationship between plasma LCAT mass concentration and plaque burden in a multi-center imaging study. METHODS Two hundred sixty-seven patients with angiographically proven coronary artery disease (CAD) underwent intravascular ultrasonography (IVUS) imaging. Ninety-six patients without CAD served as controls for biochemistry assessments. RESULTS Plasma LCAT mass concentration was higher in CAD patients as compared to controls (8.94 ± 2.51 μg/mL vs. 7.89 ± 2.99 μg/mL, p = 0.003), while cholesterol esterification rate (CER) was downregulated (253.6 ± 83.9 μM/2 h vs. 315.3 ± 115.0 μM/2 h, p
Databáze: OpenAIRE
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