A scleroderma-like cutaneous syndrome associated with a marked Th2-type immune response occurring after a prosthetic joint implant
| Autor: | Luigi Rossiello, Riccardo Giunta, Umberto De Fanis, Giacomo Lucivero, Raffaele Rossiello, Ausilia Sellitto, Ciro Romano |
|---|---|
| Přispěvatelé: | Romano, Ciro Pasquale, Sellitto, A., DE FANIS, U., Rossiello, Raffaele, Rossiello, L., Giunta, Riccardo, Lucivero, Giacomo |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty IL-4 IL-5 IL-13 Scleroderma Pathogenesis Th2 Immune system Rheumatology Fibrosis Pregnenediones Scleroderma Limited Eosinophilia Medicine Humans Arthroplasty Replacement Knee Interleukin 5 Interleukin 4 Aged integumentary system business.industry Interleukin Cobalt Syndrome Immunoglobulin E Mycophenolic Acid medicine.disease Th2 cell Erythema Immunology Cytokines Female medicine.symptom business Knee Prosthesis Immunosuppressive Agents scleroderma-like cutaneous syndrome |
| Zdroj: | Journal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases. 15(3) |
| ISSN: | 1536-7355 |
| Popis: | A scleroderma-like cutaneous syndrome, occurring after implantation of a prosthetic knee joint in an elderly woman, is reported. This case did not seem to typically fit into any of the known scleroderma-like disorders of the skin described to date. The patient was shown to be sensitized to metals contained in the prosthesis and to mount a Th2-type immune response concomitantly with development of skin fibrosis. In particular, eosinophilia, markedly elevated serum IgE levels, in vitro spontaneous production of interleukin (IL)-4 by T lymphocytes, and elevated serum levels of Th2 cytokines (namely, IL-4, IL-5, and IL-13) were observed during the acute phase of illness. Since eosinophils and such Th2 cytokines as IL-13 also have recognized fibrogenic properties, it is speculated that the pathogenesis of skin fibrosis in this case could have been the direct and/or indirect consequence of the coexisting Th2-type immune response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|