Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants and relationships with immunomarkers
| Autor: | Gustavo C. Medeiros, Madhukar H. Trivedi, Manish K. Jha, Andrew H. Czysz, Jennifer L. Furman, Joseph M. Trombello, Thomas J. Carmody, A. John Rush, Crystal Cooper |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Generalized anxiety disorder Younger age Anhedonia Article 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Valence (psychology) Aged Depressive Disorder Major business.industry Depression Cognition medicine.disease Anxiety Disorders Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Clinical Psychology Anxiety Antidepressant Major depressive disorder Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Depress Anxiety |
| Popis: | BACKGROUND Heterogeneity in major depressive disorder (MDD) is well recognized but not well understood. Core depressive features are reward and emotional symptoms, which reflect dysfunctions in the positive valence (PV) and negative valence (NV) systems, respectively. This study assessed whether PV and NV systems (based on selected symptoms) were associated with different clinical features, antidepressant response, and levels of immunomarkers in adults with MDD. METHODS These analyses used data from combining medications to enhance depression outcomes study (N = 665; n = 166 for immunomarkers). PV and NV symptom scores were extracted from the clinician-rated 30-item Inventory of Depressive Symptomatology. Correlational analyses were conducted. RESULTS PV and NV symptom scores were substantially associated with different clinical features. PV symptoms (impaired motivation, impaired energy, and anhedonia) were independently associated with female gender (p |
| Databáze: | OpenAIRE |
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