Human unrestricted somatic stem cells ameliorate sepsis‐related acute lung injury in mice
| Autor: | Zeinab Zarei Behjani, Amir Ali Hamidieh, Amir Atashi, Masoud Soleimani, Sadegh Shirian, Behnaz Taheri, Somayeh Ebrahimi-Barough, Vahid Siavashi, Jafar Ai |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Physiology medicine.medical_treatment Acute Lung Injury Clinical Biochemistry Pulmonary Edema Inflammation Lung injury Immunophenotyping Cell therapy Sepsis 03 medical and health sciences 0302 clinical medicine Immune system Animals Humans Medicine Lung business.industry Cell Biology Pulmonary edema medicine.disease respiratory tract diseases Mice Inbred C57BL Adult Stem Cells Disease Models Animal 030104 developmental biology Cytokine Liver 030220 oncology & carcinogenesis Immunology medicine.symptom business Stem Cell Transplantation Adult stem cell |
| Zdroj: | Journal of Cellular Physiology. 234:13942-13950 |
| ISSN: | 1097-4652 0021-9541 |
| DOI: | 10.1002/jcp.28077 |
| Popis: | Background Aims: Sepsis and related disorders, especially acute lung injury (ALI), are the most challenging life-threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has been introduced as a promising option to recover the sepsis symptoms. The aim of this study was to investigate the therapeutic potential of human unrestricted somatic stem cells (USSCs) isolated from human umbilical cord blood in the mouse model of ALI. USSCs significantly enhanced the survival rate of mice suffering from ALI and suppressed concentrations of proinflammatory mediators TNF-α, and interleukin (IL)-6, and the level of anti-inflammatory cytokine IL-10. ALI mice injected by USSCs showed notable reduction in lung and liver injury, pulmonary edema, and hepatic enzymes, compared with the control group. These results determined the in vivo immunomodulatory effect of USSCs for recovery of immune balance and reduction of tissue injury in the mouse model of ALI. Therefore, USSCs can be a suitable therapeutic approach to manage sepsis disease through the anti-inflammatory potential |
| Databáze: | OpenAIRE |
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