Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS)
| Autor: | Trude Helen Flo, J Barstad, P. Aukrust, Jan Kristian Damås, Linn Landrø, Stig S. Frøland, Olav Øktedalen, Thor Ueland, Fredrik Müller |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Translational Studies T cell Immunology Inflammation In Vitro Techniques Peripheral blood mononuclear cell Acquired immunodeficiency syndrome (AIDS) Bacterial Proteins Immunopathology Antiretroviral Therapy Highly Active medicine Immunology and Allergy Humans Immunodeficiency Mycobacterium avium-intracellulare Infection Acquired Immunodeficiency Syndrome biology AIDS-Related Opportunistic Infections Chemokine CCL21 Middle Aged medicine.disease biology.organism_classification Mycobacterium avium Complex Prognosis Virology Lymphatic system medicine.anatomical_structure Case-Control Studies Lentivirus Leukocytes Mononuclear Chemokine CCL19 Female medicine.symptom Biomarkers |
| Zdroj: | Clinical and experimental immunology. 167(3) |
| ISSN: | 1365-2249 |
| Popis: | Summary Based on the ability to recruit lymphocytes and dendritic cells to lymphoid tissue and to promote inflammation, we hypothesized a role for dysregulated CCL19 and CCL21 levels in human immunodeficiency virus (HIV)-infected patients with advanced immunodeficiency, and in particular in those with accompanying Mycobacterium avium complex (MAC) infection. The hypothesis was explored by studies in HIV-infected patients with and without MAC infection, as well as in vitro, examining the ability of proteins from MAC to promote CCL19 and CCL21 responses in peripheral blood mononuclear cells (PBMC) during highly active anti-retroviral therapy (HAART). Our main findings were: (i) raised serum levels of CCL19 in HIV-infected patients with CD4+ T cell count 500 cells/µl and healthy controls, with particularly high levels in those with MAC infection; (ii) elevated plasma levels of CCL19 predicted a higher mortality in acquired immune deficiency syndrome (AIDS)-patients, independent of ongoing MAC infection; and (iii) marked production of CCL19 in MAC-stimulated peripheral blood mononuclear cells (PBMC) and pronounced disturbances in MAC-induced CCL19 production in PBMC from HIV patients that was partly reversed during HAART. Our findings suggest the involvement of CCL19 in AIDS patients with advanced immunodeficiency, potentially mediating both adaptive and maladaptive responses. |
| Databáze: | OpenAIRE |
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