Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative
| Autor: | Federico Arcamone, C. Soranzo, Aurelio Di Marco, Paolo Masi, Graziella Pratesi, Anna Maria Casazza, A. Suarato, Guiseppe Cassinelli, Bernardi Luigi, Arpad Grein |
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| Rok vydání: | 1978 |
| Předmět: |
Anthracycline
Chemical Phenomena Stereochemistry chemistry.chemical_compound Mice Drug Discovery Animals Humans Leukemia L1210 Chemical decomposition Cells Cultured Biological evaluation Pharmacology chemistry.chemical_classification Antibiotics Antineoplastic biology Carubicin Glycoside biology.organism_classification Chemistry chemistry 4-O-demethyldaunorubicin Streptomyces peucetius Derivative (chemistry) HeLa Cells |
| Zdroj: | The Journal of antibiotics. 31(3) |
| ISSN: | 0021-8820 |
| Popis: | A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by application of spectroscopic methods and chemical degradation. A new synthesis of 4-O-demethyl-daunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also reported. |
| Databáze: | OpenAIRE |
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