Relationships between radiological and biochemical evidence of rickets in Asian schoolchildren
| Autor: | A.A. Abdul-Motaal, G R Sutherland, George Gettinby, M G Dunnigan, W. B. McIntosh |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Vitamin
medicine.medical_specialty Adolescent Knee Joint Population Physiology Rickets chemistry.chemical_compound Discriminant function analysis Internal medicine medicine Vitamin D and neurology Humans Prospective Studies Child Prospective cohort study education Serum Albumin Calcifediol Retrospective Studies education.field_of_study business.industry Phosphorus General Medicine Alkaline Phosphatase medicine.disease Radiography Endocrinology chemistry Alkaline phosphatase business Research Article |
| Zdroj: | Postgraduate Medical Journal. 61:307-312 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.61.714.307 |
| Popis: | Summary One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population. |
| Databáze: | OpenAIRE |
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