Conjugated dihydroxy bile salt inhibition of glucose influx in rat jejunumin vitro
| Autor: | Regina Watt, Daniel S. Feldman, Elaine B. Feldman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Taurocholic Acid
medicine.medical_specialty Physiology Salt (chemistry) In Vitro Techniques Conjugated system Chenodeoxycholic Acid Inhibitory postsynaptic potential digestive system Bile Acids and Salts Jejunum Internal medicine Abdomen medicine Animals Rat Jejunum chemistry.chemical_classification Colestipol Gastroenterology Glucose transporter Biological Transport General Medicine In vitro Rats Glucose Endocrinology medicine.anatomical_structure Intestinal Absorption chemistry Deoxycholic Acid medicine.drug |
| Zdroj: | The American Journal of Digestive Diseases. 22:415-418 |
| ISSN: | 1573-2568 0002-9211 |
| Popis: | Effects of bile salts on intestinal glucose transfer differ in diverse animal preparations exposed to various bile acids. Radiolabeled glucose influx into rat jejunum in vitro was studied in buffer and compared to taurodeoxycholate, taurochenodeoxycholate, taurocholate, and deoxycholate. Jejunum was obtained from intact, bile-diverted, and colestipoltreated rats and in similar categories after abdominal x-irradiation. Taurodeoxycholate but not taurocholate inhibited glucose influx only in bile-fistula and colestipol-treated rats. Bile diversion increased and colestipol decreased glucose uptake from buffer. Added inhibitory effects of irradiation and bile salts were seen in bile-fistula animals. These data suggest that normal exposure to bile is chronically inhibiting jejunal glucose transport and that dihydroxy bile salts are responsible for this effect. They do not provide an explanation for the role of bile in the intestinal radiation syndrome. |
| Databáze: | OpenAIRE |
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