Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification
| Autor: | Arthur C. Sinclair, Jerry R. Martin, Momir Cirovic, Richard S. Egan, Lester A. Mitscher, Alma W. Goldstein, Ruth S. Stanaszek, R. Larry De Vault, Paulette Collum, Earl E. Fager, Jack Tadanier, Sandra L. Mueller |
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| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Magnetic Resonance Spectroscopy Chemical Phenomena medicine.drug_class Stereochemistry Hydrolysis Aminoglycoside Antibiotics Molecular Conformation Glycoside Mass Spectrometry Fortimicin B Anti-Bacterial Agents Aminocyclitol Chemistry chemistry.chemical_compound Aminoglycosides chemistry Fortimicins Amide Drug Discovery medicine Mass spectrum Organic chemistry |
| Zdroj: | The Journal of Antibiotics. 30:552-563 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.30.552 |
| Popis: | The structures of fortimicins A and B have been determined by PMR, CMR, mass spectra and CD combined with chemical degradations. Both antibiotics are pseudodisaccha-rides and incorporate a novel aminocyclitol, fortamine. Incontrast to the diaminocyclitol moieties of known aminoglycosides, fortamine is a 1, 4-diamine, contains both N- and O-methyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epi-pur-purosamine B, but fort imicin A differs from fortimicin B by being a glycyl amide. |
| Databáze: | OpenAIRE |
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