Popis: |
Suppression of endothelial ERK1/1 pathways results in multi-organ failure, similar to what is observed in patients treated with anti-VEGF therapies. The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In this issue of JEM, Ricard et al. (https://doi.org/10.1084/jem.20182151) discover essential roles of ERK1/2 in maintaining endothelial homeostasis and its deletion-related serious defects in multiple tissues and organs. |