Characterization of a novel human gene containing ANK repeats and ARM domains
| Autor: | Gian Antonio Danieli, Massimiliano Olivieri, Gianluca Occhi, Alessandra Rampazzo |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
DNA
Complementary TATA box Molecular Sequence Data Biophysics Gene Expression Nerve Tissue Proteins Biology Polyadenylation Biochemistry Mice Exon Animals Humans RNA Messenger Promoter Regions Genetic Molecular Biology Gene Expressed Sequence Tags Genetics Binding Sites Base Sequence Alternative splicing TAF9 Exons Cell Biology TATA Box Introns Ankyrin Repeat Protein Structure Tertiary DNA binding site Alternative Splicing Genes Human genome Ankyrin repeat Transcription Initiation Site Sequence Alignment |
| Zdroj: | Biochemical and Biophysical Research Communications. 318:38-45 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2004.03.186 |
| Popis: | We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mammalian phylogeny. By analysing FLJ25415 gene expression in different human tissues, we demonstrated a ubiquitously expression pattern with extensive alternative splicing. In silico prediction of promoter regions revealed the presence of a TATA box and some hypothetical transcription factor binding sites, such as TMF, C/EBPalpha, LE-1, and NF-ATp. |
| Databáze: | OpenAIRE |
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