Severe Obstructive Sleep Apnea With Imaged Carotid Plaque Is Significantly Associated With Systemic Inflammation
| Autor: | Stanley Yung-Chuan Liu, Tina I. Chang, Hoang-Anh Tran, Arthur H. Friedlander, Urie K. Lee, Michelle Zeidler |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Systemic inflammation 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Myocardial infarction Endothelial dysfunction Stroke Aged Retrospective Studies Inflammation Sleep Apnea Obstructive business.industry Sleep apnea 030206 dentistry Middle Aged medicine.disease Plaque Atherosclerotic Obstructive sleep apnea Cross-Sectional Studies Atheroma Otorhinolaryngology 030220 oncology & carcinogenesis Cardiology Surgery Oral Surgery medicine.symptom business Body mass index |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 77:1636-1642 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/j.joms.2019.02.005 |
| Popis: | Purpose Persons with obstructive sleep apnea (OSA) are at heightened risk of myocardial infarction (MI) and stroke caused by adiposity and intermittent hypoxia, which provoke proinflammatory cytokines to induce systemic and vascular inflammation, resulting in endothelial dysfunction and development of atherosclerotic plaque. This study compared levels of systemic inflammation, as indexed by the neutrophil-to-lymphocyte ratio (NLR), between groups of patients with severe OSA with and without carotid artery calcified plaque (CACP+ and CACP−, respectively) on their panoramic image (PI). Materials and Methods This study had a retrospective cross-sectional study design. Medical records and PIs of men with severe OSA treated by the dental service (January 1, 2017 to December 31, 2017) were reviewed. The predictor variable was the presence or absence of CACP on PIs and the outcome variable was NLR. The t test was used to analyze differences in mean NLRs between groups. Atherogenic risk factors (age, body mass index, hypertension, and diabetes) were assessed for independence by descriptive and logistic regression analyses. Significance set at .05 for all tests. Results The study group (n = 39) of patients with CACP+ (mean age, 63 ± 7.4 yr) showed a mean NLR of 3.09 ± 1.42. The control group (n = 46) of patients with CACP− (mean age, 62 ± 6.8 yr) showed a mean NLR of 2.10 ± 0.58. The difference between groups was significant (P Conclusion Older men with severe OSA and carotid atheromas on PIs show substantially greater systemic inflammation measured by NLRs. The combination of severe OSA, atheroma formation, and markedly increased NLR suggests a higher risk of MI and stroke and greater need for cardiovascular and cerebrovascular evaluation. |
| Databáze: | OpenAIRE |
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