HNA-1a, HNA-1b and HNA-1c gene frequencies in Argentineans
| Autor: | S. Oyonarte, C. D. de La Vega Elena, N. Nogués, A. Fernández Montoya, E Solis, E. Muñiz-Díaz |
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| Rok vydání: | 2008 |
| Předmět: |
Isoantigens
Genotype Neutrophils Immunology Population Argentina Biology Biochemistry law.invention Gene Frequency Antigen law Ethnicity Genetics Humans Immunology and Allergy education Gene Allele frequency Alleles Polymerase chain reaction Human Neutrophil Antigens education.field_of_study Indians South American General Medicine Virology Neutrophil membrane |
| Zdroj: | Tissue Antigens. 71:475-477 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.2008.01034.x |
| Popis: | Human neutrophil antigens (HNA) are polymorphic structures located in the neutrophil membrane. The neutrophil-specific antigens HNA-1a (NA1), 1b (NA2) and 1c (SH) are well-recognized allotypic forms of FcgammaRIIIb and the most frequent targets of neutrophil alloantibodies. The aim of this study was to determine the gene frequencies of the neutrophil-specific antigens belonging to the HNA-1 system in blood donors and Toba Amerindians from Rosario, Argentina. Two hundred and eighteen unrelated healthy Argentinean blood donors and Toba Amerindians from Rosario were typed for HNA-1a, HNA-1b and HNA-1c using polymerase chain reaction with sequence-specific primers. For the Argentinean blood donors, the HNA-1a and HNA-1b gene frequencies were 0.44 and 0.56 and for the Amerindians Toba were 0.77 and 0.23, respectively. The HNA-1c antigen is present in 4.7% (gene frequency=0.023) of the blood donors but in none of the Amerindian individuals. The present data showed that the HNA-1 allele frequencies in the major population and the Toba Amerindians from Rosario are similar to those described in European and others distant Amerindians populations, respectively. |
| Databáze: | OpenAIRE |
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