A pilot randomized controlled trial using EEG-based brain–computer interface training for a Chinese-speaking group of healthy elderly

Autor: Yin Bun Cheung, Rachel Phillips, Tze Pin Ng, Haihong Zhang, Tih-Shih Lee, Jimmy Lee, K. Ranga Rama Krishnan, Cuntai Guan, Shin Yi Quek, Siau Juinn Alexa Goh, Lei Feng, Zheng Yang Chin, Chuanchu Wang
Rok vydání: 2015
Předmět:
Asian Continental Ancestry Group
Repeatable Battery for the Assessment of Neuropsychological Status
medicine.medical_specialty
Geriatrics & Gerontology
REPEATABLE BATTERY
Training system
Neuropsychological Tests
neuro-feedback
law.invention
cognitive training
memory
NEUROPSYCHOLOGICAL STATUS
Cognition
Asian People
Randomized controlled trial
law
General & Internal Medicine
Intervention (counseling)
PROGRAM
Humans
Learning
Medicine
Cognitive skill
OLDER-ADULTS
Aged
Original Research
Singapore
Science & Technology
business.industry
DEMENTIA
1103 Clinical Sciences
Electroencephalography
General Medicine
Confidence interval
Cognitive training
attention
ALZHEIMERS-DISEASE
Patient Satisfaction
Clinical Interventions in Aging
Brain-Computer Interfaces
Quality of Life
Physical therapy
HONG-KONG
Geriatrics and Gerontology
business
Life Sciences & Biomedicine
CLINICAL-TRIALS
Zdroj: Clinical Interventions in Aging
ISSN: 1178-1998
DOI: 10.2147/cia.s73955
Popis: Tih-Shih Lee,1 Shin Yi Quek,1 Siau Juinn Alexa Goh,1 Rachel Phillips,2 Cuntai Guan,3 Yin Bun Cheung,4 Lei Feng,5 Chuan Chu Wang,3 Zheng Yang Chin,3 Haihong Zhang,3 Jimmy Lee,6 Tze Pin Ng,5 K Ranga Rama Krishnan1 1Department of Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore; 2Singapore Clinical Research Institute, Singapore; 3Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore; 4Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore; 5Department of Psychological Medicine, National University of Singapore, Singapore; 6Department of General Psychiatry/Department of Research, Institute of Mental Health, Singapore Background: There is growing evidence that cognitive training (CT) can improve the cognitive functioning of the elderly. CT may be influenced by cultural and linguistic factors, but research examining CT programs has mostly been conducted on Western populations. We have developed an innovative electroencephalography (EEG)-based brain–computer interface (BCI) CT program that has shown preliminary efficacy in improving cognition in 32 healthy English-speaking elderly adults in Singapore. In this second pilot trial, we examine the acceptability, safety, and preliminary efficacy of our BCI CT program in healthy Chinese-speaking Singaporean elderly.Methods: Thirty-nine elderly participants were randomized into intervention (n=21) and waitlist control (n=18) arms. Intervention consisted of 24 half-hour sessions with our BCI-based CT training system to be completed in 8 weeks; the control arm received the same intervention after an initial 8-week waiting period. At the end of the training, a usability and acceptability questionnaire was administered. Efficacy was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), which was translated and culturally adapted for the Chinese-speaking local population. Users were asked about any adverse events experienced after each session as a safety measure.Results: The training was deemed easily usable and acceptable by senior users. The median difference in the change scores pre- and post-training of the modified RBANS total score was 8.0 (95% confidence interval [CI]: 0.0–16.0, P=0.042) higher in the intervention arm than waitlist control, while the mean difference was 9.0 (95% CI: 1.7–16.2, P=0.017). Ten (30.3%) participants reported a total of 16 adverse events – all of which were graded “mild” except for one graded “moderate”.Conclusion: Our BCI training system shows potential in improving cognition in both English- and Chinese-speaking elderly, and deserves further evaluation in a Phase III trial. Overall, participants responded positively on the usability and acceptability questionnaire. Keywords: cognitive training, neuro-feedback, memory, attention
Databáze: OpenAIRE