Characterization of NPM1, FLT3, and IDH1 mutations in adult patients with acute myeloid leukemia: a Brazilian cohort study

Autor:	Ana Flávia Tibúrcio Ribeiro, Evandro M. Fagundes, Saman Abbas, Ana Beatriz F. Gloria, S. Xavier, Juliana Godoy Assumpção, Silvana Maria Elói Santos, Suely M. Rezende, Nathalia G. Cruz
Rok vydání:	2016
Předmět:	Oncology Adult Male Cancer Research medicine.medical_specialty NPM1 Myeloid IDH1 Adolescent DNA Mutational Analysis Bioinformatics medicine.disease_cause Cohort Studies 03 medical and health sciences Young Adult fluids and secretions 0302 clinical medicine Gene Frequency hemic and lymphatic diseases Internal medicine medicine Humans Allele frequency Aged Aged 80 and over Mutation business.industry Myeloid leukemia Nuclear Proteins hemic and immune systems Hematology Middle Aged medicine.disease Isocitrate Dehydrogenase Leukemia Leukemia Myeloid Acute medicine.anatomical_structure fms-Like Tyrosine Kinase 3 030220 oncology & carcinogenesis embryonic structures Female business Nucleophosmin Brazil 030215 immunology Cohort study
Zdroj:	Leukemialymphoma. 57(12)
ISSN:	1029-2403
Popis:	Mutations in NPM1 (NPM1mut) and internal tandem duplication in FLT3 gene (FLT3-ITD) are the most common genetic alterations in AML. They are associated with prognosis, particularly in normal karyot...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef794e26718949cf26746fe69220e1cf https://pubmed.ncbi.nlm.nih.gov/27071442 Zobrazit plný text záznamu