Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-(4-(substituted amino)phenylalkyl)ester derivatives
| Autor: | Yutaka Ohtaki, Chikara Fukaya, Atsuyuki Ashimori, Hideaki Kido, T. Uchida, Yoshiyuki Fujino, Yoshihisa Inoue, Masahiro Eda, Satoshi Morimoto, Masahiro Watanabe, Taizo Ono, Yasushi Ogura, Kazumasa Yokoyama |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Dihydropyridines Ester derivatives Stereochemistry Nicardipine Dihydropyridine chemistry.chemical_element Biological activity General Chemistry General Medicine Calcium Ethyl ester Calcium Channel Blockers Rats Spontaneously hypertensive rat chemistry Rats Inbred SHR Drug Discovery medicine Side chain Animals Antihypertensive Agents medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 39:91-99 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Novel 1, 4-dihydropyridine derivatives bearing 3-[4-(substituted amino)phenylalkyl]ester side chains were prepared and tested for their antihypertensive activity in spontaneously hypertensive rats. Most compounds showed a more potent antihypertensive effect and a longer duration of action than nicardipine. The derivatives with a benzhydrylpiperazinyl and a benzhydrylpiperidinyl group were distinvtive. 2-[4-(4-Benzhydryl-1-piperazinyl)phenyl]ethyl methyl 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl-3, 5-pyridinedicarboxylate (4e), its 4-(4-cyano-2-pyridyl) analogue (4f), its 3-[4-(4-benzhydryl-1 piperazinyl)phenyl]propyl ester analogue (4h), its 2-[4-(4-benzhydryl-1-piperidinyl)phenyl]ethyl ester analogue (4j), and its 2-[4-(1-benzhydryl-4-piperidinyl)phenyl] ester ethyl analogue (4k) were selected as candidates for further pharmacological investigations. |
| Databáze: | OpenAIRE |
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