Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis
| Autor: | Xue Lin Zhang, Chuan Miao Xie, Xiao Fei Lv, Li Tian, Jing Li, Gui Hua Jiang, Rong Zhang, Hua Wang Wu, Lu Jun Han, Yingwei Qiu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Liver Cirrhosis Male 0301 basic medicine Hepatitis B virus medicine.medical_specialty Pathology Cirrhosis Article Subject Precuneus lcsh:Medicine Brain mapping General Biochemistry Genetics and Molecular Biology Membrane Potentials Cuneus 03 medical and health sciences 0302 clinical medicine Gyrus Internal medicine medicine Humans Cingulum (brain) Hepatic encephalopathy Brain Mapping General Immunology and Microbiology Resting state fMRI business.industry lcsh:R Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology medicine.anatomical_structure Hepatic Encephalopathy Cardiology Female business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International, Vol 2016 (2016) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | There is increasing evidence that cirrhosis may affect functional connectivity among various brain regions in patients prior to onset of overt hepatic encephalopathy (HE). However, most investigators have focused mainly on alterations in functional connectivity strengths, and the changes in functional connectivity density (FCD) are largely unknown. Here, we investigated alterations in resting-state FCD in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt HE. Totally, 31 patients with HBV-RC without overt HE and 30 age- and sex-matched healthy controls underwent resting-state functional MRI examinations. FCD mapping was employed to compute local and global FCD maps. Then, short-range and long-range FCD values were calculated and voxel-based comparisons were performed between the two groups. The HBV-RC group showed significant decreases in FCD, including decreased short-range FCDs in the bilateral middle cingulum gyrus/precuneus, the bilateral cuneus, and the left lingual gyrus/inferior occipital gyrus and decreased long-range FCD in the bilateral cuneus/precuneus. In addition, the decreased long-range FCD in the bilateral cuneus/precuneus in the HBV-RC group was related to performance on the psychometric hepatic encephalopathy score (PHES) test. These findings suggest aberrant functional connectivity density in cirrhotic patients prior to overt HE onset, which may provide better insight into understanding the pathophysiological mechanisms underlying the cirrhotic-related cognitive impairment. |
| Databáze: | OpenAIRE |
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