Radiosensitivity of the helper function of a sezary lymphocyte population
| Autor: | Bootello A, Adolfo Campos, JoséMaría Arrazola, JoséA. Brieva, Emilio G. de la Concha |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.drug_class
Lymphocyte Immunology Population Immunoglobulins chemical and pharmacologic phenomena In Vitro Techniques Lymphocyte Activation Monoclonal antibody Radiation Tolerance Pathology and Forensic Medicine Mycosis Fungoides medicine Humans Sezary Syndrome Immunology and Allergy Radiosensitivity education Sezary Cell Mycosis fungoides education.field_of_study biology Pokeweed mitogen Cell Membrane Antibodies Monoclonal T-Lymphocytes Helper-Inducer Middle Aged medicine.disease medicine.anatomical_structure biology.protein Female Mitogens Antibody |
| Zdroj: | Clinical Immunology and Immunopathology. 24:292-296 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(82)90240-9 |
| Popis: | A patient with mycosis fungoides and Sezary syndrome is described. Surface marker analysis of her peripheral blood lymphocytes revealed a phenotype characteristic of mature T helper cells (OKT3+, OKT4+). Still, a minority of lymphocytes were reactive as well with OKT8 monoclonal antibody, and most did not form E-rosettes. Patient's cells failed to produce immunoglobulin in pokeweed mitogen (PWM)-stimulated in vitro cultures. When these cells were cocultured with normal cells they were able to help but not to suppress immunoglobulin production. The helper activity was lower than that of normal T cells and markedly radiosensitive. The similarity of the immunoregulatory function of patient's Sezary cells with that of a recently reported subset of OKT4+ cells makes them a likely candidate for a neoplastic counterpart of this normal helper T-cell subset. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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