Evaluation of the Choroid in Eyes With Retinitis Pigmentosa and Cystoid Macular Edema
| Autor: | Claudio Iovino, Assaf Hilely, Michael B. Gorin, Sara Violanti, Enrico Peiretti, Adrian Au, David Sarraf |
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| Přispěvatelé: | Iovino, C., Au, A., Hilely, A., Violanti, S., Peiretti, E., Gorin, M. B., Sarraf, D. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Visual acuity genetic structures education Visual Acuity Spectral domain Severity of Illness Index Macular Edema Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vascularity Ophthalmology Retinitis pigmentosa medicine Humans In patient Macular edema Retrospective Studies Optical coherence tomography business.industry Choroid Choroidal vascularity index Retinal General Medicine Middle Aged medicine.disease eye diseases Choroidal thickne 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies chemistry 030221 ophthalmology & optometry Female sense organs medicine.symptom business Retinitis Pigmentosa Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Investigative ophthalmologyvisual science. 60(15) |
| ISSN: | 1552-5783 |
| Popis: | PURPOSE: To study the anatomical choroidal features associated with the presence of cystoid macular edema (CME) in eyes with retinitis pigmentosa (RP). METHODS: A total of 159 eyes (from 159 patients) with a diagnosis of RP were enrolled in this retrospective cross-sectional case-control study and divided into two groups based on the presence (67 eyes) or absence (92 eyes) of CME. Retinal and choroidal features were evaluated on spectral domain optical coherence tomography including central macular thickness (CMT) and subfoveal choroidal thickness (CT). Total choroidal area (TCA), choroidal luminal area (LA), and choroidal stromal area (SA) were measured and the choroidal vascularity index (CVI) was calculated in all study eyes. RESULTS: Average age was 49.2 6 14.9 and 47.1 6 15.5 years (P ¼ 0.40) and logMAR Snellen visual acuity (VA) was 0.4 6 0.6 (median 0.3, 20/40) and 0.2 6 0.4 (median 0.1, 20/25) in the RP groups with and without CME, respectively (P ¼ 0.05). Mean CMT was 334.1 6 93.5 and 252.6 6 47.6 lm in the RP groups with and without CME, respectively (P < 0.001). The subfoveal CT was significantly increased in the RP group with versus without CME (294.2 6 110.9 lm vs. 198.1 6 75.5 lm, respectively, P < 0.001). In patients with CME, the CVI was lower (P < 0.001) and the TCA, LA, and SA were all significantly higher (P < 0.001). CONCLUSIONS: In patients with CME associated with RP, the choroid exhibited significantly greater subfoveal thickening and decreased CVI. The choroid may be an important factor to consider in the etiology of CME in patients with RP. |
| Databáze: | OpenAIRE |
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