Synthesis and antibacterial evaluation of amino acid–antibiotic conjugates
| Autor: | Antoinette Birs, Juan C. Serrano, Mohamed A. Ibrahim, Claudio F. Gonzalez, Siva S. Panda, Alan R. Katritzky, Khalid A. Alamry |
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| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Clinical Biochemistry Antibiotics Sulfadiazine Pharmaceutical Science Microbial Sensitivity Tests Bacillus subtilis Quinolones medicine.disease_cause Biochemistry Microbiology Structure-Activity Relationship Metronidazole Drug Discovery Escherichia coli medicine Amino Acids Molecular Biology Dose-Response Relationship Drug Molecular Structure biology Pseudomonas aeruginosa Chemistry Organic Chemistry biology.organism_classification Quinolone Anti-Bacterial Agents Molecular Medicine Antibacterial activity medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:1856-1861 |
| ISSN: | 0960-894X |
| Popis: | Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened. |
| Databáze: | OpenAIRE |
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