Association of Rare Human Papillomavirus Types with Genital Premalignant and Malignant Lesions
| Autor: | Sören Schröder, Ernst Rudolf Beckmann, Eggert Stockfleth, Enno Christophers, Thomas F. Meyer, Lutz Gissmann, Rüdiger Arndt |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Sexually transmitted disease Pathology medicine.medical_specialty Uterine Cervical Neoplasms Biology Biopsy medicine Humans Immunology and Allergy Sex organ Typing Papillomaviridae Cervical cancer medicine.diagnostic_test Papillomavirus Infections HPV infection virus diseases Condyloma Acuminatum Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Tumor Virus Infections Squamous intraepithelial lesion Infectious Diseases Condylomata Acuminata Female Genital Diseases Female |
| Zdroj: | The Journal of Infectious Diseases. 178:252-255 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Due to the limited number of reports concerning their association with particular dysplastic and neoplastic lesions, the oncogenic potential of so-called rare or novel human papillomavirus (HPV) types is still unclear. Cytologic smears or biopsy specimens from 538 patients were analyzed for dysplastic or neoplastic lesions and HPV infection. The HPV detection and typing system utilized allowed identification of all mucosal HPVs amplifiable by L1 polymerase chain reaction. Considering only patients infected with a single HPV type (n = 329), rare or novel HPVs (HPV-59, HPV-61, HPV-62, HPV-66, HPV-70, HPV-73, MM4, MM7, MM8, CP6108, and CP8304) were detected in 28% of normal specimens (n = 46), none of condylomatous lesions (n = 44), 12% of low-grade squamous intraepithelial lesions (SILs) (n = 42), 8% of high-grade SILs (n = 142), and 4% of cervical cancers (n = 54). Prevalence and oncogenic potential of distinct rare HPV types seems to be higher than previously assumed. |
| Databáze: | OpenAIRE |
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