The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
| Autor: | Maria Laura Avantaggiati, Rami Mosaoa, Anna Kasprzyk-Pawelec, Harvey R. Fernandez |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
22.q11.2 Chromosomes Human Pair 22 Allosteric regulation lcsh:QR1-502 Regulator Organic Anion Transporters Review Mitochondrion Biochemistry lcsh:Microbiology Citric Acid Epigenesis Genetic Mitochondrial Proteins CIC 03 medical and health sciences Mice 0302 clinical medicine Cytosol Metabolic Diseases Neoplasms Diabetes Mellitus Animals Humans cancer NAFLD/NASH Citrates citrate Phosphorylation SLC25A1 Inner mitochondrial membrane Molecular Biology chemistry.chemical_classification Inflammation diabetes Chemistry Liver Diseases Transporter Metabolism Cell biology Mitochondria 030104 developmental biology Enzyme CTP 030220 oncology & carcinogenesis metabolism Allosteric Site |
| Zdroj: | Biomolecules Biomolecules, Vol 11, Iss 141, p 141 (2021) |
| ISSN: | 2218-273X |
| Popis: | The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions. |
| Databáze: | OpenAIRE |
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