Deuterated polyunsaturated fatty acids inhibit photoirradiation-induced lipid peroxidation in lipid bilayers

Autor:	A M, Firsov, M S F, Franco, D V, Chistyakov, S V, Goriainov, M G, Sergeeva, E A, Kotova, M A, Fomich, A V, Bekish, O L, Sharko, V V, Shmanai, R, Itri, M S, Baptista, Y N, Antonenko, M S, Shchepinov
Rok vydání:	2022
Předmět:	Radiation Radiological and Ultrasound Technology Tandem Mass Spectrometry Fatty Acids Lipid Bilayers Liposomes Fatty Acids Unsaturated Biophysics Radiology Nuclear Medicine and imaging Lipid Peroxidation LIPÍDEOS DA MEMBRANA Chromatography Liquid
Zdroj:	Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
ISSN:	1011-1344
DOI:	10.1016/j.jphotobiol.2022.112425
Popis:	Lipid peroxidation (LPO) plays a key role in many age-related neurodegenerative conditions and other disorders. Light irradiation can initiate LPO through various mechanisms and is of importance in retinal and dermatological pathologies. The introduction of deuterated polyunsaturated fatty acids (D-PUFA) into membrane lipids is a promising approach for protection against LPO. Here, we report the protective effects of D-PUFA against the photodynamically induced LPO, using illumination in the presence of the photosensitizer trisulfonated aluminum phthalocyanine (AlPcS
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef71766339a5d6f8602e956aa10fe04c https://doi.org/10.1016/j.jphotobiol.2022.112425 Zobrazit plný text záznamu Full Text from ScienceDirect