T-cell protein tyrosine phosphatase: A role in inflammation and autoimmunity
| Autor: | Emma I. Chistiakova, Dimitry A. Chistiakov |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Inflammation Disease Biology medicine.disease_cause Autoimmunity PTPN22 03 medical and health sciences Immune system Complementary DNA medicine Internal Medicine General autoimmunity T-cell protein tyrosine phosphate Tyrosine 030304 developmental biology chemistry.chemical_classification 0303 health sciences 030302 biochemistry & molecular biology Cytokine expression 3. Good health Enzyme chemistry Susceptibility Immunology medicine.symptom |
| Zdroj: | International Journal of Diabetes Mellitus. 2(2):114-118 |
| ISSN: | 1877-5934 |
| DOI: | 10.1016/j.ijdm.2010.05.012 |
| Popis: | A cDNA of PTPN2 encoding for T-cell protein tyrosine phosphate (TC-PTP) was isolated and characterized as long as 20 years ago. However, findings suggesting a potentially exciting role of this enzyme in general autoimmunity have only recently been obtained. Genome-wide association scans of the human genome revealed the involvement of PTPN2 in susceptibility to a several autoimmune disorders such as Crohn’s disease, type 1 diabetes, and Graves’ disease. Functional studies in immune cells revealed a key role of this enzyme in down-regulation of cytokine expression and inflammatory response, which provides an essential background to explaining the pathophysiological role of TC-PTP in autoimmunity. Thus, in addition to PTPN22 , PTPN2 is likely to represent a second member of the broad family of non-receptor PTPs contributing to general autoimmunity. |
| Databáze: | OpenAIRE |
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