Duration of protection of pentavalent rotavirus vaccination in Nicaragua
| Autor: | Jazmina Umaña, Angel Balmaceda, Manish M. Patel, Lúcia Helena de Oliveira, Juan Carlos Mercado, Jacqueline E. Tate, Martha Reyes, Alcides Gonzalez, Cristina Pedreira, Ben Lopman, Jon Kim Andrus, Maria Celina Perez, Umesh D. Parashar, Edmundo Sanchez |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Rotavirus Pediatrics medicine.medical_specialty Immunization Secondary Nicaragua Booster dose medicine.disease_cause Antibodies Viral Vaccines Attenuated Rotavirus Infections medicine Odds Ratio Humans Developing Countries business.industry Diphtheria Rotavirus Vaccines Hepatitis A Infant Odds ratio medicine.disease Rotavirus vaccine Vaccination Hospitalization Diarrhea Treatment Outcome Case-Control Studies Population Surveillance Pediatrics Perinatology and Child Health Diarrhea Infantile Female medicine.symptom business |
| Zdroj: | Pediatrics. 130(2) |
| ISSN: | 1098-4275 |
| Popis: | OBJECTIVE: To evaluate the duration of protection of pentavaent rotavirus vaccine (RV5) against rotavirus hospitalizations in Nicaragua, a developing country in Central America. METHODS: We conducted a case-control study at 4 hospitals from 2007 through 2010, including 1016 children hospitalized with laboratory-confirmed rotavirus diarrhea, 4930 controls with nonrotavirus diarrhea (ie, “test-negative”), and 5627 controls without diarrhea. All cases and controls were aged ≥6 months and born after August 2006. Outcomes included odds of antecedent vaccination between case-patients and controls, and effectiveness of vaccination (1 – adjusted odds ratio [OR] × 100). Duration of protection was assessed by comparing effectiveness among children aged RESULTS: Indicators of socioeconomic conditions and nonrotavirus vaccination (oral polio vaccine and diphtheria/tetanus/pertussis/hepatitis A/hepatitis B) for test-negative controls were more comparable to the rotavirus case-patients than nondiarrhea controls. RV5 vaccination was associated with a significantly lower risk of rotavirus hospitalization by using test-negative controls (OR: 0.55; 95% confidence interval [CI]: 0.41–0.74) and nondiarrhea controls (OR: 0.30; 95% CI: 0.22–0.40). Risk of rotavirus hospitalization was twofold lower among RV5 vaccinated children aged CONCLUSIONS: RV5 provided good protection against severe rotavirus disease in Nicaragua during the first year of life, when most severe and fatal rotavirus disease in developing countries occurs. However, the decline in protection with age warrants monitoring of disease among older children and consideration of a booster dose evaluation at the end of infancy. |
| Databáze: | OpenAIRE |
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