Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation
| Autor: | Mi Jang, Young Jin Jang, Hee Do Hong, Sungbin Choi, Seongin Jo, Tae-Gyu Lim, Eun Ju Shin, Young-Kyung Rhee, Sanguine Byun, Chang Won Cho, Won Chul Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
mitochondrial biogenesis
Pharmaceutical Science p38 Mitogen-Activated Protein Kinases Analytical Chemistry Myoblasts Ginseng Mice 0302 clinical medicine Adenosine Triphosphate Drug Discovery Myocyte 0303 health sciences Mice Inbred ICR Organelle Biogenesis Nuclear Respiratory Factor 1 red ginseng exercise endurance High Mobility Group Proteins food and beverages Cell Differentiation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Mitochondria DNA-Binding Proteins medicine.anatomical_structure Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine C2C12 Muscle tissue medicine.medical_specialty myoblast differentiation Panax Biology DNA Mitochondrial complex mixtures Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry Internal medicine Physical Conditioning Animal medicine Animals Physical and Theoretical Chemistry Muscle Skeletal Swimming 030304 developmental biology Plant Extracts Organic Chemistry AMPK Skeletal muscle TFAM Endocrinology Mitochondrial biogenesis Gene Expression Regulation Physical Endurance |
| Zdroj: | Molecules, Vol 25, Iss 4, p 865 (2020) Molecules Volume 25 Issue 4 |
| ISSN: | 1420-3049 |
| Popis: | Red ginseng has been reported to elicit various therapeutic effects relevant to cancer, diabetes, neurodegenerative diseases, and inflammatory diseases. However, the effect of red ginseng on exercise endurance and skeletal muscle function remains unclear. Herein, we sought to investigate whether red ginseng could affect exercise endurance and examined its molecular mechanism. Mice were fed with red ginseng extract (RG) and undertook swimming exercises to determine the time to exhaustion. Animals fed with RG had significantly longer swimming endurance. RG treatment was also observed to enhance ATP production levels in myoblasts. RG increased mRNA expressions of mitochondrial biogenesis regulators, NRF-1, TFAM, and PGC-1&alpha which was accompanied by an elevation in mitochondrial DNA, suggesting an enhancement in mitochondrial energy-generating capacity. Importantly, RG treatment induced phosphorylation of p38 and AMPK and upregulated PGC1&alpha expression in both myoblasts and in vivo muscle tissue. In addition, RG treatment also stimulated C2C12 myogenic differentiation. Our findings show that red ginseng improves exercise endurance, suggesting that it may have applications in supporting skeletal muscle function and exercise performance. |
| Databáze: | OpenAIRE |
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