Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate
| Autor: | Ryohei Hasegawa, Katsumi Imaida, Ken Hotta, Shoji Fukushima, Makoto Asamoto |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Sodium ascorbate
Male Cancer Research medicine.medical_specialty Sodium Urinary Bladder chemistry.chemical_element Ascorbic Acid Sodium Chloride Urine medicine.disease_cause Membrane Potentials chemistry.chemical_compound Internal medicine medicine Animals Membrane potential Urinary bladder Hyperpolarization (biology) Hydrogen-Ion Concentration Ascorbic acid digestive system diseases Epithelium Rats Inbred F344 Rats surgical procedures operative Endocrinology medicine.anatomical_structure Oncology chemistry Carcinogenesis |
| Zdroj: | Cancer letters. 63(1) |
| ISSN: | 0304-3835 |
| Popis: | We previously showed that 5% sodium l -ascorbate (Na-AsA) in the diet promotes rat urinary bladder carcinogenesis, whereas 5% ascorbic acid (AsA) and 1% sodium chloride (NaCl) in the diet do not. In order to cast light on basic properties of these compounds regarding the rat urinary bladder, we examined membrane potential levels in the bladder epithelium of F344 rats treated with 5% Na-AsA, 5% AsA or 1% NaCl in the diet for 2, 4 or 8 weeks. Microelectrode measurement showed Na-AsA to induce hyperpolarization of the membrane potential, which was, however, lacking with AsA and NaCl from week 2 until the end of experiment. Thus a good correlation between the effects on membrane potential and tumor promoting activity could be established. |
| Databáze: | OpenAIRE |
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