Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan
| Autor: | Ching Wen Tseng, Dianhua Jiang, Amber T. Kaplan, George Y. Liu, Pierre Kyme, Ramachandran Murali, Antoine Soliman, Moshe Arditi, Jiurong Liang, Stacey L. Kolar, David M. Underhill, Victor Nizet |
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| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Lipopolysaccharide Hyaluronoglucosaminidase Lung injury Biology Disaccharides medicine.disease_cause Microbiology Article Streptococcus agalactiae chemistry.chemical_compound Immune system Hyaluronidase Immunology and Microbiology(all) Virology Hyaluronic acid medicine Hyaluronic Acid Molecular Biology Immune Evasion Hydrolysis Pathogenic bacteria TLR2 chemistry Parasitology medicine.drug |
| Zdroj: | Cell Host & Microbe. 18:694-704 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2015.11.001 |
| Popis: | In response to tissue injury, hyaluronan (HA) polymers are cleaved by host hyaluronidases, generating small fragments that ligate Toll-like receptors (TLRs) to elicit inflammatory responses. Pathogenic bacteria such as group B Streptococcus (GBS) express and secrete hyaluronidases as a mechanism for tissue invasion, but it is not known how this activity relates to immune detection of HA. We found that bacterial hyaluronidases secreted by GBS and other Gram-positive pathogens degrade pro-inflammatory HA fragments to their component disaccharides. In addition, HA disaccharides block TLR2/4 signaling elicited by both host-derived HA fragments and other TLR2/4 ligands, including lipopolysaccharide. Application of GBS hyaluronidase or HA disaccharides reduced pulmonary pathology and pro-inflammatory cytokine levels in an acute lung injury model. We conclude that breakdown of host-generated pro-inflammatory HA fragments to disaccharides allows bacterial pathogens to evade immune detection and could be exploited as a strategy to treat inflammatory diseases. |
| Databáze: | OpenAIRE |
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