MDR1 Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV-1 or Disease Progression before Treatment
| Autor: | Matthias Egger, Gabriela Bleiber, Catia Marzolini, Carlos Suarez, Amalio Telenti, Raquel Martinez, Margaret T May |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Permissiveness
CD4-Positive T-Lymphocytes Genotype HIV Infections 610 Medicine & health physiological processes Virus Cohort Studies Acquired Immunodeficiency Syndrome/*genetics/physiopathology Base Sequence CD4-Positive T-Lymphocytes/immunology Cohort Studies DNA Primers Disease Progression Genes MDR/*genetics Genotype HIV Infections/*genetics/physiopathology Hiv-1 Humans *Polymorphism Genetic Variation (Genetics) 360 Social problems & social services Immunopathology polycyclic compounds Immunology and Allergy Humans Allele neoplasms DNA Primers Acquired Immunodeficiency Syndrome Polymorphism Genetic biology Base Sequence Haplotype Genetic Variation biology.organism_classification Virology Infectious Diseases Lentivirus Immunology Disease Progression HIV-1 Viral disease Genes MDR |
| Zdroj: | Journal of Infectious Diseases, vol. 189, no. 4, pp. 583-6 Bleiber, Gabriela; May, Margaret; Suarez, Carlos; Martinez, Raquel; Marzolini, Catia; Egger, Matthias; Telenti, Amalio (2004). MDR1 Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV-1 or Disease Progression before Treatment. Journal of infectious diseases, 189(4), pp. 583-586. The University of Chicago Press 10.1086/380134 |
| Popis: | Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment. |
| Databáze: | OpenAIRE |
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