Effect of oral proguanil on human lymphocyte proliferation
| Autor: | H. Flachs, Ib C. Bygbjerg |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Cycloguanil Time Factors Proguanil Lymphocyte Endogeny Pharmacology Biology Lymphocyte Activation Leukocyte Count chemistry.chemical_compound parasitic diseases Leukocytes medicine Humans Pharmacology (medical) Lymphocytes Phytohemagglutinins Active metabolite Triazines General Medicine In vitro Pyrimethamine medicine.anatomical_structure chemistry Antifolate human activities Thymidine medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 30:249-251 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00614314 |
| Popis: | In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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