Synthetic idiotypes: the third hypervariable region of murine anti-dextran antibodies
| Autor: | Richard A. Houghten, Mcmillan Seamus L H, B. Clevinger, Joseph M. Davie, M.V. Seiden, Richard A. Lerner |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Antiserum
Idiotype Gel electrophoresis chemistry.chemical_classification biology Myeloma protein Immunoglobulin Variable Region Peptide Dextrans Molecular biology General Biochemistry Genetics and Molecular Biology Epitope Hypervariable region Epitopes Mice Myeloma Proteins Biochemistry chemistry Immunoglobulin Idiotypes Antibody Specificity biology.protein Animals Antibody Oligopeptides |
| Zdroj: | Cell. 35(3 Pt 2) |
| ISSN: | 0092-8674 |
| Popis: | Synthetic peptides with the sequence of the third hypervariable region of either M104 or J558 murine myeloma proteins have been used to immunize rabbits. Most of the resulting antisera distinguished the two proteins in a specific manner corresponding to the sequence of the immunizing peptide. Thus synthetic peptides have been used to elicit antisera specific for particular idiotypes. These studies have significant implications for our understanding of the molecular basis of idiotypy. |
| Databáze: | OpenAIRE |
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