Allogeneic stem-cell transplantation for renalcellcancer
| Autor: | Hitendra R.H. Patel, Manit Arya, Jean V. Joseph, Dickon Hayne, Ciaran Lynch, Lyndon M. Gommersall |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Disease urologic and male genital diseases Antigen Internal medicine medicine Carcinoma Humans Transplantation Homologous Carcinoma Renal Cell Aged Chemotherapy business.industry Immunotherapy Middle Aged medicine.disease Kidney Neoplasms Transplantation Immunology Cell cancer Stem cell business Stem Cell Transplantation |
| Zdroj: | The Lancet Oncology. 5:561-567 |
| ISSN: | 1470-2045 |
| DOI: | 10.1016/s1470-2045(04)01568-2 |
| Popis: | Summary Metastatic renal-cell carcinoma (RCC) is resistant to chemotherapy, and patients with this disease have a poor outlook. Immunotherapy by use of cytokines and vaccines against tumour antigens has shown encouraging results in a small group of patients. Advances in the understanding of the graft-versus-tumour effect in haematological malignant disorders have led to the use of stem-cell transplantation for treatment of solid-organ malignant diseases such as RCC. Techniques of bone-marrow ablation have been superseded by safer conditioning regimens, with occasional complete remission and partial remission in some patients. Graftversus- host disease, engraftment failure, and disease progression remain important obstacles to the widespread use of new techniques for metastatic RCC. Here, we summarise important issues surrounding immunotherapy for RCC, the problems encountered with use of immunotherapy, and the present use of non-myeloablative techniques for treatment of this disease. |
| Databáze: | OpenAIRE |
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